A las puertas del desarrollo

Treball Final de Grau en Periodisme. Codi: PE0932. Curs acadèmic: 2017/201

Referencias mitológicas sintoístas en la serialidad animada japonesa

La animación japonesa se ha ido extendiendo a lo largo de los años hasta ser un hito en occidente. Estas series animadas comprenden una gran variedad de géneros dirigidos a diferentes tipos de audiencia que aseguran su consumo y ofrecen historias distintas a las que se cuentan en series occidentales basándose en la cultura del país como el sintoísmo. La influencia de esta religión ofrece una gama de posibilidades a la hora de crear y enriquecer la trama. El objetivo de este trabajo es analizar los rasgos influenciados por la mitología sintoísta y el grado de interpretación que tienen a la hora introducirlos en las series seleccionadas: Naruto, Death Note, Inuyasha y Bleach. La investigación cuenta con una parte de visualizado de los casos de estudio y una recopilación de datos sobre la cultura y la religión japonesa, usando como fuentes tanto autores reconocidos sobre el tema como fuentes más casuales como blogs de aficionados, para tener una amplia base donde apoyar el análisis. A lo largo del documento, se exponen los conceptos que han sido empleados en estas series y se compara la reinterpretación de estos, mostrando las distintas formas en la que los autores incluyen su cultura en sus obras. Con este estudio, podemos observar el contenido subyacente que posee el anime que va más allá de la excentricidad que presenta visualmente.Japanese animation has extended over the years and it has become a huge hit in the western countries. These animated shows include a great variety of genres aimed to different types of audience that ensure their viewing and they offer stories unlike those told on the western animations by basing them in the country¿s culture like shintoism. This religion¿s influence offers a wide range of possibilities when creating and improving the storyline. The objective is to analyze the traits influenced by shintoist mythology and to examine the degree of interpretation the selected shows possess. This series are Naruto, Death Note, Inuyasha and Bleach. The research is formed by the visualization of the cases of study and a recompilation of data about the culture and the religion of Japan. It uses sources of different origins, such as recognised authors of the matter as well as casual blogs of enthusiasts, to develop a broad data base in which we support the analysis. Throughout the document, it is exposed the concepts utilized in these series and it is compared the reinterpretation between them to show the various ways the authors include their culture in their work. With this study, we can observe the subjacent content that the anime possesses that goes beyond the eccentricity of its aesthetics.Reche Peris, A. (2018). Referencias mitológicas sintoístas en la serialidad animada japonesa. Universitat Politècnica de València. http://hdl.handle.net/10251/116027TFG

Atopic Dermatitis in the Elderly Population

Acta DermatoVenereologica Atopic dermatitis is a common inflammatory disease with a chronic and relapsing course. Although considered a childhood disease, it is now evident that atopic dermatitis is also common in adulthood and in the elderly population. Atopic dermatitis typically manifests with bilateral and symmetrical eczematous lesions on the face, trunk and skin folds. Itch is invariably present and may be very severe, markedly affecting daily life and sleep. In older adults, atopic dermatitis may have a high level of impact on quality of life, frequently burdening an already complex comorbid situation. The full assessment of disease burden (localizations, itch severity, sleep alterations, impact on quality of life, disease history, comorbidities) is crucial to identify the most appropriate treatment. In many cases, moderate-to-severe atopic dermatitis in the elderly population can be successfully and safely treated with biological agents inhibiting the interleukin-4/-13 pathway, whereas the use of Janus kinase inhibitors may pose concerns about the safety profile

AtopyReg®, the Prospective Italian Patient Registry for Moderate‐to‐Severe Atopic Dermatitis in Adults: Baseline Demographics, Disease Characteristics, Comorbidities, and Treatment History

Background and Objective AtopyReg® is a multicenter, prospective, observational, non-profit cohort study on moderate-tosevere atopic dermatitis in adults promoted in 2018 by the Italian Society of Dermatology and Venereology (SIDeMaST). We aimed to describe baseline demographics, disease characteristics, comorbidities, and therapeutic data of adult patients affected by moderate-to-severe atopic dermatitis. Methods Patients were selected based on the following inclusion criteria: age ≥ 18 years; Eczema Area and Severity Index score ≥ 16 or localization in visible or sensitive areas (face, neck, hands, or genitalia), or a Numeric Rating Scale itch score ≥ 7 or a Numeric Rating Scale sleep loss score ≥ 7, or a Dermatology Life Quality Index score ≥ 10. Demographic and clinical data at baseline were recorded and analyzed. Results A total of 1170 patients (male 51.1%; mean age: 44.7 years; range 18–90 years) were enrolled by 12 Italian Dermatology Units between January 2019 and November 2022. Skin lesions were eczematous in 83.2% of patients, the most involved site were the flexures (53.9%), face (50.9%), and neck (48.0%). Mean Eczema Area and Severity Index score was 22.3, mean Dermatology Life Quality Index value was 17.6, mean Patient Oriented Eczema Measure score was 13.1, and mean Numeric Rating Scale itch and sleep loss scores were 7.6 and 5.9, respectively. Previous systemic therapies were corticosteroids in 77.7% of patients, antihistamines in 50.3% of patients, and cyclosporine A in 42.6% of patients. Conclusions This baseline data analysis deriving from AtopyReg ® provides real-life evidence on patients with moderateto- severe atopic dermatitis in Italy confirming the high burden of atopic dermatitis with a significant impact on patients’ quality of life

IL-17 Inhibition: A Valid Therapeutic Strategy in the Management of Hidradenitis Suppurativa

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a significant negative impact on the quality of life of patients. To date, the therapeutic landscape for the management of the disease has been extremely limited, resulting in a profound unmet need. Indeed, adalimumab, an anti-tumor necrosis factor (TNF)-α monoclonal antibody, is the only approved biologic agent for HS, obtaining a therapeutic response in only 50% of HS patients. Numerous clinical trials are currently ongoing to test novel therapeutic targets in HS. The IL-17-mediated cascade is the target of several biologic agents that have shown efficacy and safety in treating moderate-to-severe HS. Both bimekizumab and secukinumab, targeting IL-17 in different manners, have successfully completed phase III trials with promising results; the latter has recently been approved by EMA for the treatment of HS. The aim of this review is to summarize the current state of knowledge concerning the relevant role of IL-17 in HS pathogenesis, highlighting the key clinical evidence of anti-IL-17 agents in the treatment of this disease

Análisis de conflictos en educación física en una unidad didáctica de raquetas en el CEIP María Moliner

El presente Trabajo de Fin de Grado se basa en analizar el origen de diversos conflictos surgidos en el área de Educación Física, en base a una Unidad Didáctica de raquetas desarrollada en el CEIP María Moliner de Zaragoza durante mis prácticas de mención, con alumnos de dos clases de 3º de Educación Primaria, de 8 años de edad. El instrumento utilizado para la recogida de datos y su posterior análisis han sido grupos de discusión. Las referencias obtenidas fueron codificadas a partir de un sistema de categorías con ayuda del programa QSR-NVIVO 12, lo que facilitó su análisis para la obtención de los resultados. Estos resultados muestran de manera general las respuestas de los alumnos en base a los conflictos originados por la organización de las tareas, por el cumplimiento de las normas y por las relaciones sociales. En conclusión, el alumnado considera positiva la presencia de normas que favorezcan la convivencia y el bienestar en la escuela y optan por el diálogo o recurrir al profesor como principales métodos de resolución de conflictos.<br /

Vacuum-assisted closure device enhances recovery of critically ill patients following emergency surgical procedures

Introduction: Critically ill surgical patients frequently develop intra-abdominal hypertension (IAH) leading to abdominal compartment syndrome (ACS) with subsequent high mortality. We compared two temporary abdominal closure systems (Bogota bag and vacuum-assisted closure (VAC) device) in intra-abdominal pressure (IAP) control. Methods: This prospective study with a historical control included 66 patients admitted to a medical and surgical intensive care unit (ICU) of a tertiary care referral center (Careggi Hospital, Florence, Italy) from January 2006 to April 2009. The control group included patients consecutively treated with the Bogota bag (Jan 2006-Oct 2007), whereas the prospective group was comprised of patients treated with a VAC. All patients underwent abdominal decompressive surgery. Groups were compared based upon their IAP, SOFA score, serial arterial lactates, the duration of having their abdomen open, the need for mechanical ventilation (MV) along with length of ICU and hospital stay and mortality. Data were collected from the time of abdominal decompression until the end of pressure monitoring. Results: The Bogota and VAC groups were similar with regards to demography, admission diagnosis, severity of illness, and IAH grading. The VAC system was more effective in controlling IAP (P < 0.01) and normalizing serum lactates (P < 0.001) as compared to the Bogota bag during the first 24 hours after surgical decompression. There was no significant difference between the SOFA scores. When compared to the Bogota, the VAC group had a faster abdominal closure time (4.4 vs 6.6 days, P = 0.025), shorter duration of MV (7.1 vs 9.9 days, P = 0.039), decreased ICU length of stay (LOS) (13.3 vs 19.2 days, P = 0.024) and hospital LOS (28.5 vs 34.9 days; P = 0.019). Mortality rate did not differ significantly between the two groups. Conclusions: Patients with abdominal compartment syndrome who were treated with VAC decompression had a faster abdominal closure rate and earlier discharge from the ICU as compared to similar patients treated with the Bogota bag

Dupilumab improves clinical manifestations, symptoms, and quality of life in adult patients with chronic nodular prurigo

Background: Chronic nodular prurigo (CNPG) is a multifactorial skin disease characterized by itchy papules and nodules, usually resistant to standard treatment and associated with markedly impaired quality of life. Objective: To describe dupilumab effectiveness and tolerability in treating adult patients with CNPG refractory to both topical and systemic therapies. Methods: Retrospective, multicenter study including adult patients affected by CNPG, who were treated with dupilumab for at least 16 weeks. Results: Twenty-seven CNPG patients showed clinical improvement in terms of skin lesions, itch, sleeplessness, and quality of life. A consistent proportion of patients (24/27; 88.9%) had at least 16-week continuous treatment and achieved Investigator Global Assessment score 1 (11/24; 45.8%). An increased number of patients achieved at least a 2-grade reduction in Investigator Global Assessment score (19/24; 79.2%). Numeric rating scale values for itch and sleeplessness decreased from 8.9 to 2.7 and from 8.2 to 1.7, respectively (P .001) after 16-week therapy. Ten patients achieved 36 weeks of continuous treatment while maintaining clinical efficacy. Limitations: Major limitations included lack of validated assessment tools at the initial data collection, a limited cohort of treated patients, and a short-term observation period. Conclusion: Dupilumab was proven effective in reducing itch and improving CNPG skin lesions

Feasibility of inter-hospital transportation using extra-corporeal membrane oxygenation (ECMO) support of patients affected by severe swine-flu(H1N1)-related ARDS

<p>Abstract</p> <p>Background</p> <p>To describe the organization of an ECMO-centre from triage by telephone to the phase of inter-hospital transportation with ECMO of patients affected by H1N1-induced ARDS, describing techniques and equipment used.</p> <p>Methods</p> <p>From September 2009 to January 2010, 18 patients with H1N1-induced ARDS were referred to our ECMO-centre from other hospitals. Six patients had contraindications to treatment with ECMO and remained in the local hospital. Twelve patients were transported to our centre and were included in this study. Four patients were transported on ECMO (Group A) and eight on conventional ventilation (Group B). The groups were compared on the basis of adverse events during transport, clinical characteristics and outcome.</p> <p>Results</p> <p>The PaO2/FiO2 ratio was lower in the patients of Group A (46.8 vs 89.7 [median]) despite the PEEP values being higher (15.0 vs 8.5 [median]). The Murray score was higher in Group A (3.50 vs 2.75 [median]). During the transfer there were no significant complications noted in Group A, whereas two patients in Group B were reported with hypoxia (SpO2 < 90%). One patient in Group A died. All the other patients of the two groups have been discharged from hospital.</p> <p>Conclusions</p> <p>The creation of an ECMO team, with various experts in the treatment of ARDS, assured a safe transfer of patients with severe hypoxia, over long distances, when in other cases they wouldn't have been be transportable.</p